Study type: Medical/biological study (experimental study)

Cytogenetic effects of exposure to 2.3 GHz radiofrequency radiation on human lymphocytes in vitro. med./bio.

Published in: Anticancer Res 2009; 29 (11): 4323-4330

Aim of study (acc. to author)

To study if exposure used in mobile phones and wireless network technologies would induce DNA damage in cultured human lymphocytes (from six smoking or non-smoking donors) with and without clastogen mitomycin C (co-exposure) for one full cell cycle.

Background/further details

In some cell cultures DNA synthesis (hydroxyurea) and DNA repair (caffeine) were inhibited. Positive controls and negative controls were included in each experiment.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 2.3 GHz
Modulation type: pulsed
Exposure duration: one cell cycle
Exposure 2: 2.3 GHz
Modulation type: CW
Exposure duration: one cell cycle

Exposure 1

Main characteristics
Frequency 2.3 GHz
Type
Exposure duration one cell cycle
Modulation
Modulation type pulsed
Duty cycle 50 %
Repetition frequency 200 Hz
Exposure setup
Exposure source
Distance between exposed object and exposure source 1.2 m
Chamber 5 m x 4 m x 4 m anechoic chamber
Setup rectangular horn antennas with an aperture of 6 cm x 8 cm placed facing upward under the samples;
Parameters
Measurand Value Type Method Mass Remarks
power density 10 W/m² average over time measured - -

Exposure 2

Main characteristics
Frequency 2.3 GHz
Type
Exposure duration one cell cycle
Modulation
Modulation type CW
Exposure setup
Exposure source
Parameters
Measurand Value Type Method Mass Remarks
power density 10 W/m² average over time measured - -
electric field strength 61 V/m - - - -

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

No statistically significant differences were found between control and exposed cultures with or without mitomycin C, for any of the chromosomal parameters for any of the donors in the uninhibited assay or in the cell cultures where DNA synthesis and DNA repair were inhibited.
A weak trend towards more chromosomal damage from pulsed wave rather than continuous wave exposure was observed as well as a weak trend for more chromosomal damage with the interaction of pulsed electromagnetic fields with mitomycin C (compared to a continuous wave exposure).

Study character:

Study funded by

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