Study type: Medical/biological study (experimental study)

Absence of mutagenic interaction between microwaves and mitomycin C in mammalian cells med./bio.

By: Meltz ML, Eagan P, Erwin DN
Published in: Environ Mol Mutagen 1989; 13 (4): 294-303
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Aim of study (acc. to author)

Two hypothesis were tested: a) that radiofrequency radiation (RFR) by itself can cause an increase in mutation in a mammalian cell in vitro mutation assay system; and b) that a simultaneous exposure to RFR during a chemical treatment of the cells with the genotoxic chemical mitomycin C will result in either an increase or a decrease in the extent of mutagenesis induced by the treatment of the cells by the chemical alone.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 2.45 GHz
Modulation type: pulsed
Exposure duration: 4 h
  • SAR: 30 mW/g unspecified (unspecified)
  • power density: 488 W/m² unspecified (at the table surface.)

Exposure 1

Main characteristics
Frequency 2.45 GHz
Type
Waveform
Charakteristic
Exposure duration 4 h
Modulation
Modulation type pulsed
Pulse width 10 µs
Duty cycle 0.25 %
Repetition frequency 25,000 Hz
Exposure setup
Exposure source
Distance between exposed object and exposure source 1.6 m
Chamber water bath placed in anechoic chamber / 40 ft x 20 ft x 10 ft
Setup 10 flasks placed on the Styrofoam wheel, which was placed in water bath.
Parameters
Measurand Value Type Method Mass Remarks
SAR 30 mW/g unspecified calculated unspecified -
power density 488 W/m² unspecified measured - at the table surface.

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

Radiofrequency radiation alone, at moderate power levels which resulted in a temperature increase in the cell culture medium less than 3°C, is not mutagenic. When cells are simultaneously treated with mitomycin C and radiofrequency radiation (RFR) at these same moderate power levels, the RFR does not affect either the inhibition of cell growth or the extent of mutagenesis resulting from treatment with mitomycin C alone.

Study character:

Study funded by

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