Study type: Medical/biological study (experimental study)

In vitro studies of microwave-induced cataract: reciprocity between exposure duration and dose rate for pulsed microwaves. med./bio.

Published in: Exp Eye Res 1985; 40 (1): 1-13

Aim of study (acc. to author)

To investigate the effects of pulsed microwave irradiation on rat eye lens in vitro.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 918 MHz
Modulation type: pulsed
Exposure duration: continuous for 6, 20, and 60 min

Exposure 1

Main characteristics
Frequency 918 MHz
Type
Charakteristic
  • guided field
Exposure duration continuous for 6, 20, and 60 min
Modulation
Modulation type pulsed
Pulse width 10 µs
Additional info

Repetition rates were varied to obtain various average powers. In some preliminary experiments, pulse durations of 20 µs were used.

Exposure setup
Exposure source
Setup Lenses were maintained at constant temperature by circulating phosphate buffered saline (PBS) in a thermostatically-controlled exposure cell placed in a WR975 waveguide as previously described [Stewart-De Haan et al., 1983].
Sham exposure A sham exposure was conducted.
Parameters
Measurand Value Type Method Mass Remarks
power 24 kW peak value - - transmitted power
SAR 1,300 mW/g mean measured - 65 W
SAR 400 mW/g mean measured - 20 W
SAR 120 mW/g mean measured - 6 W
SAR 40 mW/g mean measured - 2 W
SAR 20 mW/g mean measured - 1 W
SAR 10 mW/g mean measured - 0.5 W

Reference articles

Methods Endpoint/measurement parameters/methodology

Investigated system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

Different kinds of damage, such as subcapsular foam, holes in fibre cells and granulation of cell surface could be detected. A clear tendency of increasing depth of damage with increasing duration of exposure and dose rate could be observed. Lens fibre cell damage could be detected by scanning electron microscopy after 6 min irradiation at SAR values of 20 and 40 mW/g. After 1 h exposure at SAR values of 10 mW/g fibre cell damage could be detected by light microscopy.

Study character:

Study funded by

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