Study type: Medical/biological study (experimental study)

Changes in gap junctional intercellular communication in rabbits lens epithelial cells induced by low power density microwave radiation. med./bio.

Published in: Chin Med J (Engl) 2002; 115 (12): 1873-1876

Aim of study (acc. to author)

To study the changes in gap junctional intercellular communication mediated by low power density microwave exposure in rabbits eye lens epithelial cells and its mechanisms.

Background/further details

16 rabbits were investigated: 8 rabbits were used for investigation of gap junctional intercellular communication function (4 rabbits received 5 mW/cm², 4 rabbits received 10 mW/cm²). The other 8 rabbits were used for detection of localization and function of connexin 43. One eye served as experimental eye while the other eye served as control.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 2,450 MHz
Exposure duration: continuous for 3 h

Exposure 1

Main characteristics
Frequency 2,450 MHz
Type
Exposure duration continuous for 3 h
Exposure setup
Exposure source
Distance between exposed object and exposure source 2 m
Setup The head of the rabbit was fixed at the distance of 2 m from the emission machine, and one open eye was exposed.
Additional info The other eye served as control and was covered tightly by copper grid cloth shielding material.
Parameters
Measurand Value Type Method Mass Remarks
power density 5 mW/cm² - measured - -
power density 10 mW/cm² - measured - -

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

The gap junctional intercellular communication of eye lens epithelial cells was inhibited by microwave irradiation especially in the 10 mW/cm² exposed samples. A decrease in connexin 43-positive staining was found in 5 mW/cm² treated eye lens epithelial cells.
In conclusion, low power densities microwave irradiation induces damage to connexin 43 and inhibits the gap junctional intercellular communication of eye lens epithelial cells. These changes result in an osmotic imbalance within the eye lens and induce early cataract.

Study character:

Study funded by

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