Study type: Medical/biological study (experimental study)

Proteomic analysis of human lens epithelial cells exposed to microwaves. med./bio.

Published in: Jpn J Ophthalmol 2007; 51 (6): 412-416

Aim of study (acc. to author)

This study was performed to investigate proteome changes in human lens epithelial cells exposed to 1800 MHz Global System for Mobile Communication-like microwaves in vitro and to get further insights into the molecular mechanisms of microwave-induced cartaract formation.

Background/further details

The experiments were conducted in triplicate. Three different specific absorption rates were used: 1, 2, and 3.5 W/kg.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 1,800 MHz
Modulation type: pulsed
Exposure duration: continuous for 2 h

Exposure 1

Main characteristics
Frequency 1,800 MHz
Type
Exposure duration continuous for 2 h
Modulation
Modulation type pulsed
Repetition frequency 217 Hz
Exposure setup
Exposure source
Sham exposure A sham exposure was conducted.
Parameters
Measurand Value Type Method Mass Remarks
SAR 1 W/kg - - - -
SAR 2 W/kg - - - -
SAR 3.5 W/kg - - - -

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

No proteome changes were observed in cells exposed to microwaves at 1 W/kg.
The protein profiles of exposed cells at specific absorption rates of 2 and 3.5 W/kg compared to those of sham-exposed cells showed four upregulated proteins. Further analysis revealed heat-shock protein 70 and heterogeneous nuclear ribonucleoprotein K (RNA-binding protein, amongst others involved in signal transduction and gene expression) to be upregulated in the exposed cells.

Study character:

Study funded by

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