To study the genotoxic potential of 42.2 GHz electromagnetic millimeter waves in mice.
Groups of animals that were injected with cyclophosphamide (15 mg/kg body weight), a drug used in the treatment of human malignancies, were also included to examine if millimeter wave irradiation had any influence on drug-induced genotoxicity.
| Exposure | Parameters |
|---|---|
|
Exposure 1:
42.2 GHz
Exposure duration:
repeated daily exposure, 30 min/day for 3 consecutive days
|
|
| Frequency | 42.2 GHz |
|---|---|
| Charakteristic | |
| Exposure duration | repeated daily exposure, 30 min/day for 3 consecutive days |
| Exposure source | |
|---|---|
| Distance between exposed object and exposure source | 0.005 m |
| Setup | The animals were restrained in individual high density polypropylene centrifugal tubes with a 9 mm-diameter opening in which the nose was stuck. The antenna was positioned 5 mm from the tip of the horn. |
| Measurand | Value | Type | Method | Mass | Remarks |
|---|---|---|---|---|---|
| power density | 315 W/m² | mean | calculated | - | - |
| SAR | 622 W/kg | mean | calculated | unspecified | - |
The data showed that the incidence of micronuclei in 2000 polychromatic erythrocytes was not significantly different among untreated, exposed, and sham-exposed mice. Mice that were injected with cyclophosphamide exhibited significantly increased numbers of micronuclei. The drug-induced micronuclei were not significantly different in exposed and sham-exposed mice. Thus there was no evidence for the induction of genotoxicity in the peripheral blood and bone marrow cells of mice exposed to electromagnetic millimeter waves. Also, millimeter wave exposure did not influence cyclophosphamide-induced micronuclei in either type of cells.
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