Study type: Medical/biological study (experimental study)

Alternating extremely low frequency magnetic field increases turnover of dopamine and serotonin in rat frontal cortex. med./bio.

Published in: Bioelectromagnetics 2004; 25 (6): 426-430

Aim of study (acc. to author)

To investigate the effects of extremely low frequency magnetic fields on brain levels of some biogenic amines in rat.

Background/further details

The endogenous levels of the following biogenic amines and metabolites were determined: dopamine, 3,4-dihydroxyphenylacetic acid, homovanillic acid, 3-methoxytyramine, 5-hydroxytryptamine, 5-hydroxyindoleacetic acid, and noradrenaline. Also the turnover of dopamine and 5-hydroxytryptamine was determined via an enzymatic test.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 10 Hz
Exposure duration: repeated daily exposure, 1 h/day for 14 days

Exposure 1

Main characteristics
Frequency 10 Hz
Type
Waveform
Exposure duration repeated daily exposure, 1 h/day for 14 days
Exposure setup
Exposure source
Setup Animals were placed in a specially designed plastic chamber that was fitted inside the cylindrical applicator of the magnetic therapy device "Ambient 2000"
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 1.8 mT effective value measured - to 3.8 mT maximum value

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

It was found that 1 h daily exposure for 2 weeks to extremely low frequency magnetic fields did not alter the endogenous levels of the examined amines and metabolites. However, the rate of synthesis (turnover) of dopamine and 5-hydroxytryptamine was increased.

Study character:

Study funded by

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