Study type: Medical/biological study (experimental study)

Blood-forming system in rats after whole-body microwave exposure; reference to the lymphocytes med./bio.

By: Trosic I, Busljeta I, Pavicic I
Published in: Toxicol Lett 2004; 154 (1-2): 125-132
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Aim of study (acc. to author)

To investigate the influence of 2.45 GHz microwave irradiation on blood-forming cells after whole-body irradiation of rats.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 2.45 GHz
Modulation type: CW
Exposure duration: repeated daily exposure, 2 h/day, for 2, 8, 15, and 30 days

Exposure 1

Main characteristics
Frequency 2.45 GHz
Type
Charakteristic
Exposure duration repeated daily exposure, 2 h/day, for 2, 8, 15, and 30 days
Modulation
Modulation type CW
Exposure setup
Exposure source
  • modified MW oven generator
Distance between exposed object and exposure source 1.4 m
Chamber Animals were placed in individual Plexiglas cages.
Setup The experimental design has been described in detail in [Trosic et al., 2002].
Sham exposure A sham exposure was conducted.
Additional info The groups of exposed (n = 40) and sham-exposed (n = 24) animals were each divided into 4 subgroups corresponding to the exposure duration.
Parameters
Measurand Value Type Method Mass Remarks
power density 10 mW/cm² mean measured - 5-10 mW/cm²
SAR 2 W/kg mean estimated whole body 1-2 W/kg
Measurement and calculation details

The field power density within the individual cages was measured using an EM Radiation Monitor. Mean whole-body SARs were estimated according to a Radiation Dosimetry Handbook [Durney et al., 1980].

Reference articles

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • before exposure
  • after exposure

Main outcome of study (acc. to author)

Significant decrease in lymphoblast count was obtained at 15 and 30th experimental day, whereas other parameters did not significantly differed in comparison to the sham-exposed controls. The data point out at stress response in blood-forming system in rats after selected microwave exposure, which could be considered rather as sign of adaptation than malfunction.

Study character:

Study funded by

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