Study type: Medical/biological study (experimental study)

Radio frequency radiation effects on protein kinase C activity in rats' brain. med./bio.

Published in: Mutation Research - Fundamental and Molecular Mechanism of Mutagenesis 2004; 545 (1-2): 127-130

Aim of study (acc. to author)

To study the effect of amplitude modulated radiofrequency irradiation on calcium-dependent protein kinase C (PKC) activity on developing rat brain.

Background/further details

PKC was determined in whole brain, hippocampus and whole brain minus hippocampus separately.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 112 MHz
Modulation type: AM
Exposure duration: repeated daily exposure, 2 h/day for 35 days

Exposure 1

Main characteristics
Frequency 112 MHz
Exposure duration repeated daily exposure, 2 h/day for 35 days
Modulation
Modulation type AM
Modulation frequency 16 Hz
Modulation depth 50 %
Exposure setup
Exposure source
Chamber rectangular Plexiglas cage/32 x 10 x 9 cm
Setup two rats were restrained and exposed at a time
Parameters
Measurand Value Type Method Mass Remarks
power density 10 W/m² unspecified unspecified - -
SAR 1.48 mW/g mean unspecified whole body -

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

A significant decrease in the enzyme level was revealed in the exposed animals in comparison to the sham-exposed animals (whole brain and hippocampus). The phenomen is non-thermal in nature. These findings indicate that this type of irradiation could affect membrane bound enzymes associated with cell signaling, proliferation and differentiation. This may also suggest an effect on the behavior of chronically exposed rats.

Study character:

Study funded by

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