Study type: Medical/biological study (experimental study)

Protein kinase C activity in developing rat brain cells exposed to 2.45 GHz radiation. med./bio.

Published in: Electromagn Biol Med 2006; 25 (1): 61-70

Aim of study (acc. to editor)

To study the effect of 2.45 GHz exposure on calcium-dependent protein kinase C (PKC) enzyme activity and morphological changes in the developing rat brain.

Background/further details

PKC was determined in the whole brain, hippocampus and whole brain minus hippocampus separately of six rats (35 days old). Morphological changes were investigated in additional six rats.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 2.45 GHz
Modulation type: pulsed
Exposure duration: continuous for 2 h/day on 35 days

Exposure 1

Main characteristics
Frequency 2.45 GHz
Type
Exposure duration continuous for 2 h/day on 35 days
Modulation
Modulation type pulsed
Duty cycle 25 %
Exposure setup
Exposure source
Setup wooden anechoic chamber lined on the inside with pyramidal black radar absorbing material (40 dB); horn antenna positioned at one end of the chamber at a distance of 2 d²/λ from the cage; six rats placed individually in one of the six compartments (arranged in 2 columns and 3 rows) of a 43 cm x 27 cm x 15 cm Plexiglas cage inside the chamber; cage and chamber ventilated and temperature kept constant at 30°C; animals restraint during exposure
Sham exposure A sham exposure was conducted.
Parameters
Measurand Value Type Method Mass Remarks
power 1.2 mW - measured - -
power density 0.344 mW/cm² - - - -
SAR 0.11 W/kg - calculated whole body -

Reference articles

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

The data revealed a statistically significant decrease in PKC enzyme activity in the hippocampus and the whole brain when compared with the rest of the brain (whole brain - hippocampus) and compared with the control group.
Additionally, glial cell population was increased in the exposed group as compared with the control group.
The authors conclude that chronic exposures may affect brain growth and brain development.

Study character:

Study funded by

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