Study type: Medical/biological study (experimental study, theoretical study)

Formulation of ELF magnetic fields' effects on malondialdehyde level and myeloperoxidase activity in kidney using genetic programming. med./bio.

Published in: Comput Methods Programs Biomed 2007; 86 (1): 1-9

Aim of study (acc. to author)

This study was designed to investigate whether effects of extremely low frequency magnetic fields on malondialdehyde level and myeloperoxidase activity can be appropiately analysed and formulated by a computer method.

Background/further details

A total of 54 male, 250-300 grams weighted, 10-12 weeks old, guiena pigs were used. Experimental results were compared to the results calculated by use of genetic programming (GP). Genetic programming belongs to evolutionary algorithms based on the principles of genetics and natural selections. It can be applid when biological effects are not measurable precisely as in this study the myeloperoxidase activity.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 50 Hz
Exposure duration: 4 h/day or 8 h/day for 5 days

Exposure 1

Main characteristics
Frequency 50 Hz
Type
Exposure duration 4 h/day or 8 h/day for 5 days
Exposure setup
Exposure source
Setup animals in 26 cm x 22 cm x 10 cm plastic cages in the center of the coil
Sham exposure A sham exposure was conducted.
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 1 mT minimum - - -
magnetic flux density 2 mT - - - -
magnetic flux density 3 mT maximum - - -

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

It was found that genetic programming showed high accuracy and can be therefore effectively used to model malondialdehyde level and myeloperoxidase activity.

Study character:

Study funded by

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