Study type: Review (medical/biological study)

In vivo effects of ELF MFs on collagen synthesis, free radical processes, natural antioxidant system, respiratory burst system, immune system activities, and electrolytes in the skin, plasma, spleen, lung, kidney, and brain tissues. review

Published in: Electromagn Biol Med 2006; 25 (4): 291-305

Aim of study (acc. to author)

To study the effects of extremely low frequency electromagnetic field on skin, immune system, electrolytes concentrations in guinea pigs and drug induced epileptic seizure in mice.

Background/further details

The study summarized previous published (see publication 7584 and publication 13912) and unpublished data of the authors work on different experimental set ups and compared the results to those of similar other studies.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 50 Hz
Exposure duration: 4 h/day or 8 h/day for 5 days
guinea pigs
Exposure 2: 50 Hz
Exposure duration: 1 h
mice

Exposure 1

Main characteristics
Frequency 50 Hz
Type
Waveform
Exposure duration 4 h/day or 8 h/day for 5 days
Additional info guinea pigs
Exposure setup
Exposure source
Setup 2 parallel circular coils 21.375 cm apart with a common axis ; each coil with a diameter of 42.75 cm and 154 turns of insulated copper wire; animals in the center of the exposure system
Sham exposure A sham exposure was conducted.
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 1 mT minimum - - -
magnetic flux density 2 mT - - - -
magnetic flux density 3 mT maximum - - -

Exposure 2

Main characteristics
Frequency 50 Hz
Type
Waveform
Exposure duration 1 h
Additional info mice
Exposure setup
Exposure source
Sham exposure A sham exposure was conducted.
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 0.2 mT - - - -

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

Extremely low frequency electromagnetic field exposure at magnetic flux density of 2 mT increased statistically significant hydroxyproline content of the skin compared to control group.
Statistical significant difference between electromagnetic field exposed group and control group were observed in increased plasma Ca2+ concentration.
In lung and kidney, exposure to 1 mT and 2 mT increased malondialdehyde concentration in four hours exposure/day whereas they caused a decrease in eight hours exposure/day. In brain significant increase in malondialdehyde concentration was observed in eight hours exposure/day at 2 mT.
Electromagnetic fields caused significant increase in lung tissue nitric oxide levels.
Increased renal myeloperoxidase activities were found for all magnetic field exposures and exposure periods.
No significant effect of electromagnetic field exposure on drug induced epileptic seizure was found.
These results indicate that extremely low frequency electromagnetic field has effects on the tissues examined.

Study character:

Exposure

Study funded by