Study type: Medical/biological study (experimental study)

Microwaves from UMTS/GSM mobile phones induce long-lasting inhibition of 53BP1/gamma-H2AX DNA repair foci in human lymphocytes. med./bio.

Published in: Bioelectromagnetics 2009; 30 (2): 129-141

Aim of study (acc. to author)

To study the effects of UMTS/GSM mobile phone microwaves on chromatin and 53BP1/gamma-H2AX DNA repair foci in human lymphocytes from hypersensitive and healthy persons.

Background/further details

Two samples with lymphocytes from healthy donors (4 women, 1 man) and patients reporting hypersensitivity to electromagnetic fields (4 women, 1 man) were exposed to either GSM or UMTS mobile phone microwaves and sham exposure. A 1h heat treatment was used as a positive control for stress response. As a positive control for genotoxic effect, the cells were irradiated with gamma radiation.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 905–915 MHz
Exposure duration: 1 h
Exposure 2: 1,947.4 MHz
Exposure duration: 1 h

Exposure 1

Main characteristics
Frequency 905–915 MHz
Type
Exposure duration 1 h
Exposure setup
Exposure source
Setup output of the mobile phone was connected via a coaxial cable to the TEM-cell
Sham exposure A sham exposure was conducted.
Parameters
Measurand Value Type Method Mass Remarks
power 0.25 W - - - output
SAR 37 mW/kg - measured and calculated - for 915 MHz

Exposure 2

Main characteristics
Frequency 1,947.4 MHz
Type
Exposure duration 1 h
Additional info middle channel, 5 MHz wide band
Exposure setup
Exposure source
Sham exposure A sham exposure was conducted.
Parameters
Measurand Value Type Method Mass Remarks
power 0.25 W - - - output
SAR 40 mW/kg - measured and calculated - for 1947 MHz

Reference articles

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Time of investigation:
  • before exposure
  • after exposure

Main outcome of study (acc. to author)

In the present study, microwaves from UMTS/GSM mobile phones (at athermal levels lower than the ICNIRP safety standards) affected chromatin conformation and inhibited formation of 53BP1/gamma-H2AX DNA repair foci in human lymphocytes from hypersensitive and healthy persons. These effects depended on carrier frequency and type of signal. The effects on 53BP1/gamma-H2AX DNA repair foci persisted up to 72 h following exposure, longer than the stress response following heat shock. No significant differences between groups of healthy and hypersensitive persons were observed, except for the effects of UMTS mobile phone microwaves and GSM-915 MHz mobile phone microwaves on the formation of the DNA repair foci, which were different for hypersensitive but not for control persons.

Study character:

Study funded by

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