Study type: Epidemiological study (observational study)

Case-only study of interactions between DNA repair genes (hMLH1, APEX1, MGMT, XRCC1 and XPD) and low-frequency electromagnetic fields in childhood acute leukemia. epidem.

Published in: Leuk Lymphoma 2008; 49 (12): 2344-2350

Aim of study (acc. to author)

A case-only study was conducted among ethnic Han Chinese children in China to investigate the role of interactions between low-frequency electromagnetic fields and DNA repair enzymes in childhood leukemia.

Further details

The hypothesis should be tested whether genetic variations of DNA repair genes could contribute to the individual susceptibility to childhood leukemia.

Endpoint/type of risk estimation

Exposure

Assessment

Exposure groups

Group Description
Reference group 1 electric transformers and powerlines within 500 m from houses: no
Group 2 electric transformers and powerlines within 500 m from houses: yes
Reference group 3 electric transformers and powerlines within 100 m from houses: no
Group 4 electric transformers and powerlines within 100 m from houses: yes
Reference group 5 electric transformers and powerlines within 50 m from houses: no
Group 6 electric transformers and powerlines within 50 m from houses: yes

Population

Study size

Type Value
Total 123
Statistical analysis method: ( adjustment: )

Conclusion (acc. to author)

The combined analyses of DNA repair genes and environment showed that an interaction existed between electric transformers and power lines situated within 100 m of the houses and the presence of XRCC1 Ex9+16A allele in childhood acute leukemia (case-only OR 4.31, CI 1.54-12.08), within 50 m the OR was increased further (case-only OR 4.39, CI 1.42-13.54). No significant interactions between the proximity of the electric transformers and power lines and the other genotypes of DNA repair genes were observed.
The results suggested a possible association between electric transformers and power lines and the presence of XRCC1 Ex9+16A allele in patients with childhood acute leukemia.

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