Study type: Medical/biological study (experimental study)

Experimental study of millimeter wave-induced differentiation of bone marrow mesenchymal stem cells into chondrocytes med./bio.

Published in: Int J Mol Med 2009; 23 (4): 461-467

Aim of study (acc. to author)

The study describes the effects of millimeter wave treatment on cultured mesenchymal stem cells of rats and attempts to identify the underlying mechanism.

Background/further details

Low power millimeter wave irradiation is widely used in clinical medicine. Bone marrow mesenchymal stem cells are adult stem cells that possess multiple differentiation potentials.



Exposure Parameters
Exposure 1:
  • unspecified
Exposure duration: continuous for 30 min or 60 min

Exposure 1

Main characteristics
  • unspecified
Exposure duration continuous for 30 min or 60 min
Additional info wavelength between 7.5 mm and 10 mm
Exposure setup
Exposure source
Measurand Value Type Method Mass Remarks
power density 4,000 kW/cm² - - - -

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

The data showed that daily millimeter wave exposure under these experimental conditions for 30 and 60 minutes can successfully induce bone marrow mesenchymal stem cells to differentiate into chondrocytes that excrete chondrocyte-specific matrix glycosaminoglycan and type II collagen. The results also indicate that the 60 minutes treatment was more effective than the 30 minutes treatment. The underlying mechanisms may be related to the up-regulation of Sox9 and Cbfa1 mRNA, which elevates glycosaminoglycan and type II collagen production. Further research is needed to study the complexities of mesenchymal stem cell differentiation.

Study character:

Study funded by

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