The study investigated the ability of millimeter waves to promote the differentiation of rat primary bone marrow stromal cells into cells with a neural phenotype, in an attempt to provide experimental basis for the future clinical application.
Exposure duration: 10 minutes, three times at an interval of 2 h
|Exposure duration||10 minutes, three times at an interval of 2 h|
|power density||10 mW/cm²||-||measured||-||-|
The untreated bone marrow stromal cells predominately expressed nucleostemin (a marker protein of stem cells prior to differentiation). After treatment by beta-mercaptoethanol and millimeter waves, the cells exhibited a dramatic decrease in nucleostemin expression and increase in neuron-specific enolase expression (a marker protein for neurons). The differentiation rate of the cells treated with beta-mercaptoethanol and millimeter wave exposure in combination was significantly higher than that of the cells treated with beta-mercaptoethanol alone.
The authors conclude that millimeter wave exposure enhanced the inducing effect of beta-mercaptoethanol on the differentiation of bone marrow stromal cells into cells with a neural phenotype.