Study type: Medical/biological study (experimental study)

Induction of Hair Growth by Insulin-Like Growth Factor-1 in 1,763 MHz Radiofrequency-Irradiated Hair Follicle Cells. med./bio.

Published in: PLoS One 2011; 6 (12): e28474

Aim of study (acc. to author)

To study the effect of 1763 MHz radiofrequency exposure on cultured human dermal papilla cells by evaluating changes in the expression of cytokines related to hair growth.

Background/further details

Additional cell lines were used for comparison.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 1,763 MHz
Exposure duration: continuous for 1 h or 3 h
Exposure 2: 1,763 MHz
Exposure duration: continuous for 1 h/day for 7 days

Exposure 1

Main characteristics
Frequency 1,763 MHz
Type
Exposure duration continuous for 1 h or 3 h
Additional info in vitro
Exposure setup
Exposure source
  • monopole
Setup rectangular cavity-type chamber in TE102 mode; monopole antenna positioned at λ/8 position at the cavity's top plate; cells placed at λ/4 position in the chamber in 100 mm-dishes with a layer thickness of 4 mm; chamber equipped with a cooling device
Sham exposure A sham exposure was conducted.
Parameters
Measurand Value Type Method Mass Remarks
SAR 2 W/kg - - - -
SAR 10 W/kg - - - -

Exposure 2

Main characteristics
Frequency 1,763 MHz
Type
Exposure duration continuous for 1 h/day for 7 days
Additional info ex vivo
Exposure setup
Exposure source
Sham exposure A sham exposure was conducted.
Parameters
Measurand Value Type Method Mass Remarks
SAR 10 W/kg - - - -

Reference articles

  • Lee JS et al. (2006): Radiofrequency radiation does not induce stress response in human T-lymphocytes and rat primary astrocytes.

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

The expression of insulin-like growth factor-1 (IGF-1) mRNA in human dermal papilla cells was significantly induced upon radiofrequency exposure (at a SAR value of 10 W/kg), which resulted in increased expression of Bcl-2 and cyclin proteins and increased phosphorylation of the MAPK-1 protein. However, the expression of other growth factors (VEGF, HGF and TGF-beta1) was not changed.
Exposure to 10 W/kg radiofrequency irradiation 1 h per day for 7 days significantly enhanced hair shaft elongation in ex vivo hair organ cultures. In exposed follicular matrix keratinocytes in the hair bulb, the expression of Ki-67 antigen was increased, while the TUNEL-positive cells were decreased.
The authors suggest that 1763 MHz radiofrequency exposure stimulates hair growth in vitro through the induction of IGF-1 in human dermal papilla cells.

Study character:

Study funded by

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