Study type: Medical/biological study (experimental study)

Effects of radiofrequency radiation and simultaneous exposure with mitomycin C on the frequency of sister chromatid exchanges in Chinese hamster ovary cells. med./bio.

Published in: Environ Mutagen 1987; 9 (4): 393-399

Aim of study (acc. to author)

To determine if 1) radiofrequency radiation (RFR) alone (2450 MHz, pulsed wave) can induce sister chromatid exchange (SCE) formation in Chinese hamster ovary cells, and 2) RFR during simultaneous treatment with mitomycin C (MMC) under the same conditions can cause a change in frequency in SCEs beyound that which is produced by the MMC alone.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 2.45 GHz
Modulation type: pulsed
Exposure duration: up to 3 h

General information

cells were treated in the following groups: i) control ii) EMF iii) Mitomycin (MMC) added iv) EMF + MMC v) sham

Exposure 1

Main characteristics
Frequency 2.45 GHz
Type
Exposure duration up to 3 h
Modulation
Modulation type pulsed
Pulse width 10 µs
Duty cycle 25 %
Repetition frequency 25 kHz
Exposure setup
Exposure source
Distance between exposed object and exposure source 1.6 m
Setup 12.2 m x 6.1 m x 3.1 m anechoic chamber; exposuer flasks in water bath
Sham exposure A sham exposure was conducted.
Parameters
Measurand Value Type Method Mass Remarks
power density 49 mW/cm² spatial average measured - -
SAR 33.8 W/kg - calculated - -

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

1) Pulsed wave RFR at the specific field parameters (i.e. at a moderate power density and SAR) has no effect on sister chromatid exchange (SCE) induction in CHO cells, and is unlikely to be genotoxic. 2) A simultaneous treatment with MMC and RFR did nor result in an increase SCE frequency over that caused by MMC treatment alone.

Study character:

Study funded by

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