Study type: Medical/biological study (experimental study)

Effects of exposure to 50 Hz or 20 kHz magnetic fields on weights of body and some organs of CBA mice. med./bio.

Published in: In Vivo 1998; 12 (3): 293-298

Aim of study (acc. to author)

To evaluate possible effects of magnetic field exposure on body and organe weight during mice development

Background/further details

Two strains of mice were exposed to magnetic fields (50 Hz or 20 kHz) according to different time schedules. Experiment 1: From the first day of conception until 280 days of age 50 Hz); experiment 2: 140 days, starting at an age of 84 days (50 Hz); experiment 3: for 20, 30, 40, and 60 days, respectively, starting at an age of 29 days (50 Hz or 20 kHz); experiment 4: for 1, 2, or 4 days, respectively,starting at an age of 21 day (50 Hz); experiment 5: for 90 days, starting at an age of 30 day (50 Hz).

Endpoint

Exposure

Exposure Parameters
Exposure 1: 50 Hz
Exposure duration: Experiment 1*: throughout pregnancy + 280 days of age, experiment 2: 140 days, experiment 3: 20 days, 30 days, 40 days and 60 days, experiment 4: 1 day, 2 days and 4 days, experiment 5: 90 days
Exposure 2: 20 kHz
Modulation type: pulsed
Exposure duration: Experiment 3: 20 days, 30 days, 40 days or 60 days

Exposure 1

Main characteristics
Frequency 50 Hz
Type
Waveform
Exposure duration Experiment 1*: throughout pregnancy + 280 days of age, experiment 2: 140 days, experiment 3: 20 days, 30 days, 40 days and 60 days, experiment 4: 1 day, 2 days and 4 days, experiment 5: 90 days
Exposure setup
Exposure source
Chamber Three specially made racks with coils. One rack was used for 50 Hz exposure, the second one for 20 kHz exposure ands the third one used for sham in which the coils were not connected to current source.
Additional info *In experiment 1, mice mated while being exposed to magnetic field. The exposure was continued with the pregnant mice until day 20 after birth and was carried on with the off spring till 280 days of age. In experiment 2: adult mice were exposed. In experiment 3, 4 and 5, young mice were exposed.
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 14 µT peak value unspecified - -

Exposure 2

Main characteristics
Frequency 20 kHz
Type
Waveform
  • sawtooth-shaped
Exposure duration Experiment 3: 20 days, 30 days, 40 days or 60 days
Modulation
Modulation type pulsed
Rise time 20 µs
Fall time 5 µs
Exposure setup
Exposure source
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 15 µT peak value unspecified - -

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
  • body weight, some organ weight
Time of investigation:
  • during exposure
  • after exposure

Main outcome of study (acc. to author)

A significantly lower body weight as well as liver and kidney weights were found in male mice exposed during fetal stages up to 280 days These results were not seen in female mice (exp. 1). A lower growth was found in mice exposed for 140 days (exp. 2). Kidney and liver weights were significantly reduced in mice exposed for 90 days (exp. 5).
The authors conclude that the observed effects depend on exposure time. In addition, young mice and male mice were found to be more senistive. The effects of 50 Hz exposure where larger than at 20 kHz.

Study character:

Study funded by

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