Study type: Medical/biological study (experimental study)

Extended exposure of adult and fetal mice to 50 Hz magnetic field does not increase the incidence of micronuclei in erythrocytes. med./bio.

Published in: Bioelectromagnetics 2001; 22 (5): 351-357

Aim of study (acc. to author)

This study was performed to investigate the effects of electromagnetic field on micronuclei formation in erythrocytes of both adult and fetal mice.

Background/further details

The study included two different experiments:1.) 20 adult mice (7-8 weeks old, 10 female, 10 male) exposed for 18 days, and 2.) 20 mice exposed in utero during first 18 days of gestation. 35 days after exposure was terminated, peripheral blood was drawn from the offspring exposed in utero to determine whether the exposure had a genotoxic effect on the pluripotent erythroid stem cells.
The positive controls were gamma radiated mice.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 50 Hz
Exposure duration: 18 days (exposed or sham exposed)

Exposure 1

Main characteristics
Frequency 50 Hz
Type
Waveform
Exposure duration 18 days (exposed or sham exposed)
Additional info Reference article: Svedenstal BM, Johanson CJ, Leukocytes and micronucleated erythrocytes in peripheral blood from mice exposed to 50 Hz or 20 kHz magnetic fields. Electro- and megneto-biology 17:127-143, 1998
Exposure setup
Exposure source
Chamber cages in different racks equipped with current coils
Additional info sham exposure mice placed in identical racks
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 100 nT peak value cf. remarks unspecified 0.7 µT; Stray fields in control racks
magnetic flux density 14 mT peak value cf. remarks unspecified vertical

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

After the electromagnetic field exposure of mice, adult and offspring, no effects on micronuclei formation in erythrocytes or body weight could be found.

Study character:

Study funded by

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