Study type: Medical/biological study (experimental study)

Effects of pulsed magnetic fields on the developing mouse embryo (incl. Erratum). med./bio.

Published in: Bioelectromagnetics 1993; 14 (3): 197-204

Aim of study (acc. to author)

To investigate the effects of a 20 kHz pulsed magnetic field on embryogenesis in mice.

Background/further details

Five experiments differing only in the start of exposure were conducted (i.e. magnetic field exposure began on day 1 of gestation (experiment 1 and 2), on day 2, on day 5, and on day 7 in experiments 3, 4, and 5, respectively). All exposures continued until day 19 post conception.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 20 kHz
Modulation type: pulsed
Exposure duration: 12, 14, 18, or 19 days

General information

Field strength apparently was measured, but details are not mentioned. The experimental field appeared homogenous, with an overlapping 39-46 µT static magnetic field.

Exposure 1

Main characteristics
Frequency 20 kHz
Type
Exposure duration 12, 14, 18, or 19 days
Modulation
Modulation type pulsed
Rise time 45 µs
Fall time 5 µs
Repetition frequency 20 Hz
Exposure setup
Exposure source
Chamber racks
Setup mice placed in cages kept in racks
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 15 µT peak value measured - -

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

A significantly higher placental resorption rate was observed in all groups when compared with controles, except in experiment 5. A increased malformation rate was not seen in any of the groups. Body mass and lenght were significantly reduced only in experiment 5. The number of dead fetuses was affected in experiment 1.
The Authors annotated that the effects of magnetic field exposure might be strain-related, because an increased number of resorptions has not been observed in other strains of mice.

Study character:

Study funded by

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