Study type: Medical/biological study (experimental study)

Fetal loss in mice exposed to magnetic fields during early pregnancy. med./bio.

Published in: Bioelectromagnetics 1995; 16 (5): 284-289

Aim of study (acc. to author)

To investigate the effects of a 20 kHz pulsed magnetic field on early fetal loss as well as progesterone and calcium-levels in pregnant mice.

Background/further details

Magnetic field exposure was applied from day 1 to day 5.5 or from day 1 to day 7 of pregnancy. The preimplantation periode in mice, from fertilization until implantation of the embryo in the uterus, takes 5.5 days. All animals were sacrificed for examination on day 19, one day before birth.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 20 kHz
Modulation type: pulsed
Exposure duration: continuous for 5 1/2 or 7 days

Exposure 1

Main characteristics
Frequency 20 kHz
Type
Waveform
  • sawtooth-shaped
Exposure duration continuous for 5 1/2 or 7 days
Additional info Exposure setup was described in detail in Frölen et al.1993
Modulation
Modulation type pulsed
Pulse width 50 µs
Rise time 40 µs
Fall time 10 µs
Exposure setup
Exposure source
Chamber racks
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 15 µT peak value measured - at the racks

Reference articles

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

As compared with sham control, no significant increase of early fetal death was observed in exposed animals. The lenght and body weight of living embryos was significantly decreased in animals exposed for 5.5 days. Progesterone and calcium levels in dames were not significantly altered due to magnetic field exposure, except on day 3 and day 13 when progesteron and calcium levels were found to be elevated in exposed dams, respectively.

Study character:

Study funded by

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