Study type: Medical/biological study (experimental study)

The effects of 30 mT electromagnetic fields on hippocampus cells of rats. med./bio.

Published in: Surg Neurol Int 2016; 7: 70-

Aim of study (acc. to author)

The effects of exposure of rats to a 50 Hz magnetic field on ultrastructure and apoptosis in the hippocampus should be investigated.

Background/further details

24 rats were divided into two groups (n=12 each): 1) exposure to the magnetic field and 2) control group.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 50 Hz
Exposure duration: 4 hours/day for 10 weeks

Exposure 1

Main characteristics
Frequency 50 Hz
Type
Exposure duration 4 hours/day for 10 weeks
Exposure setup
Exposure source
Setup the system consisted of 2 windings of opposite direction which produced a uniform field in the center of the device where animals were located
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 3 mT - - - -

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

In ultrastructural investigations, hippocampus samples of exposed rats showed some glial cells with a dense core and compact chromatin and mitochondria with vague cristae. Nerve cells in the exposure group were damaged, with compact chromatin and a decreased amount of intracellular organelles. Moreover, vacuoles were visible and intracellular organelles such as the mitochondria were morphologically abnormal and uncertain. In the control group, these features were not detected.
The number of apoptotic cells was significantly increased in the exposure group compared to the control group.
The authors conclude that exposure to a 50 Hz magnetic field might change the ultrastructure and increase apoptosis in the hippocampus of rats.

Study character:

Study funded by

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