Study type: Medical/biological study (experimental study)

Exposure of Sprague-Dawley rats to a 50-Hertz, 100-microTesla magnetic field for 27 weeks facilitates mammary tumorigenesis in the 7,12-dimethylbenz[a]-anthracene model of breast cancer. med./bio.

Published in: Cancer Res 1999; 59 (15): 3627-3633

Aim of study (acc. to author)

To investigate the effects of a 27 week magnetic field exposure on DMBA induced tumor development in rats.

Background/further details

After one week of magnetic field or sham exposure 10 mg/rat DMBA was administered and exposure or sham exposure was continued for 26 weeks.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 50 Hz
Modulation type: CW
Exposure duration: 24 h/day, 7 days/week, for 27 weeks

Exposure 1

Main characteristics
Frequency 50 Hz
Type
Waveform
Polarization
Exposure duration 24 h/day, 7 days/week, for 27 weeks
Additional info horizontal
Modulation
Modulation type CW
Exposure setup
Exposure source
Chamber exposure chambersa, 9 rats/cage
Setup Mf horizontal and parallel to horizontal component of the earth's MF
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 100 µT effective value - - -
electric field strength 60 V/m maximum cf. remarks - 20-60 V/m

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
  • breast
Time of investigation:
  • during exposure
  • after exposure

Main outcome of study (acc. to author)

Magnetic field exposure enhanced tumor development and growth significantly, detected by palpation. The incidence of histologically verified mammary tumors was statistically significant higher in exposed rats compared with sham-exposed animals.

Study character:

Study funded by

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