Study type: Medical/biological study (experimental study)

Chronic toxicity/oncogenicity evaluation of 60 Hz (power frequency) magnetic fields in B6C3F1 mice. med./bio.

Published in: Toxicol Pathol 1999; 27 (3): 279-285

Aim of study (acc. to author)

The aim of this in vivo study was to evaluate the possible oncogenic and toxic effects in mice exposed to chronic biennial extremely low frequency magnetic field in mice.

Background/further details

Altogether 200 male and 200 female mice were examined.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 60 Hz
Modulation type: CW
Exposure duration: 18.5 h/day, 7 days/week, for 104 weeks (1 h on /1 h off)

Exposure 1

Main characteristics
Frequency 60 Hz
Type
Waveform
Polarization
Exposure duration 18.5 h/day, 7 days/week, for 104 weeks (1 h on /1 h off)
Modulation
Modulation type CW
Exposure setup
Exposure room 5 identical animal exposure rooms, polycarbonate cages on fiberglass cage racks
Setup cages rotated 2/week, racks rotated 1/week, experimental groups rotated 1/10 weeks
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 1 mT maximum - - -
magnetic flux density 0.2 mT - - - -
magnetic flux density 2 µT minimum - - -

Reference articles

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

A small statistical significant increase in mortality was observed in male mice exposed continuously to 10 G magnetic fields. The mortality patterns in all other groups of mice exposed to magnetic fields were comparable to those found in sex-matched sham controls.
The magnetic field exposure did not increase the incidence of neoplasia in any organ.
A statistically significant decrease in the incidence of malignant lymphoma was observed in female mice exposed continuously to 10 G magnetic fields, and statistically significant decreases in the incidence of lung tumors were seen in both sexes exposed continuously to 2 G magnetic fields.
These results do not indicate any significant oncogenic or toxic effect of the chronic exposure to pure, linearly polarized 60 Hz magnetic fields in mice.

Study character:

Study funded by

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