Study type: Medical/biological study (observational study)

The effect of vitamin E and C on comet assay indices and apoptosis in power plant workers: A double blind randomized controlled clinical trial. med./bio.

Published in: Mutat Res Genet Toxicol Environ Mutagen 2020; 850–851: 503150

Aim of study (acc. to author)

The effects of an administration of vitamin C and vitamin E on genotoxicity in blood cells from power plant workers should be investigated.

Background/further details

A total of 81 employees from different parts of a thermal power plant were divided into the following groups: 1) vitamin E administration (400 units/day) (n=20), 2) vitamin C administration (1000 mg/day) (n=21), 3) vitamin E + C administration (n=21), 4) control group (sham administration) (n=19). All participants received their administrations for 3 months, before and afterwards blood samples were collected.

Endpoint

Exposure

Exposure Parameters
Exposure 1:
Exposure duration: at least 2 years job experience before beginning of intervention, 3 months in a full time job during intervention

Exposure 1

Main characteristics
Frequency
Type
Exposure duration at least 2 years job experience before beginning of intervention, 3 months in a full time job during intervention
Exposure setup
Exposure source
Setup participants included technicians, operators, engineers and office workers from the power plant
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 16.5 µT mean measured - ± 6.46 µT
electric field strength 22.5 V/m mean measured - ± 5.38 V/m

Reference articles

  • Cam ST et al. (2011): Occupational exposure to magnetic fields from transformer stations and electric enclosures in Turkey.

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

Some comet assay parameters were significantly decreased in the vitamin E group (group 1), vitamin C group (group 2) and vitamin E+C group (groups 3) after the treatment period compared to before (remark EMF-Portal: the exact parameters are presented ambiguously in the article). No significant differences were found in the control group (group 4). None of the apoptosis parameters showed any significant changes in any group. (remark EMF-Portal: no results are shown for the general symptoms.)
The authors concluded that an administration of vitamin C and vitamin E might protect blood cells from power plant workers against genotoxic effects.

Study character:

Study funded by

Related articles