The effects of occupational exposure to high-voltage power lines (50/60 Hz) on oxidative stress and oxidative DNA damage in workers urine and the protective effect of green tea polyphenols should be investigated.
Several studies have found a protective effect of green tea polyphenols against oxidative damage, what should now be tested in electro-magnetic field exposure.
Participants consisted of substation workers with occupational exposure to 110-420 kV lines as exposed subjects and subjects who work in administration as non-exposed subjects. Both groups were randomly divided into two subgroups: placebo and green tea polyphenol supplementation (GTPS) for 12 months. The capsules were orally administered twice daily and contained 250 mg of green tea extract without caffeine. The following groups were used in the study: 1) occupational exposure and placebo (n=67), 2) no exposure and placebo (n=54), 3) occupational exposure and GTPS (n=123), 4) no exposure and GTPS (n=77).
|Exposure duration||approximately 8 hours/day|
|Setup||working in a 110-420 kV substation|
No parameters are specified for this exposure.
Prior to the GTPS treatment, subjects from the exposure groups (groups 1 and 3) showed significantly higher levels of oxidative stress and oxidative DNA damage compared to the control groups (groups 2 and 4). After 12 months of GTPS treatment (group 3), the values were significantly reduced compared to the initial value, while there were no significant changes observed in the placebo group (group 1).
3 months after the end of GTPS treatment, oxidative stress and DNA damage were again increased to the initial levels before GTPS treatment in group 3, which revealed the reversible effect of GTPS.
The authors conclude that occupational exposure to high-voltage power lines (50/60 Hz) might induce oxidative stress and oxidative DNA damage and that green tea polyphenol supplementation might protect against these effects.