Study type: Medical/biological study (observational study)

Investigating the effects of vitamins E and C on oxidative stress and hematological parameters among power plant workers: A double-blind randomized controlled clinical trial. med./bio.

Published in: Toxicol Ind Health 2020; 36 (2): 99-109

Aim of study (acc. to author)

The effects of an administration of vitamin C and vitamin E on oxidative stress and hematological parameters in power plant workers should be investigated.

Background/further details

A total of 81 employees from different parts of a power plant were divided randomly into the following groups: 1) vitamin E administration (400 units/day) (n=21), 2) vitamin C administration (1000 mg/day) (n=20), 3) vitamin E + C administration (n=21), 4) control group (sham administration) (n=19). All participants received their administrations for 90 days, before and afterwards blood samples were collected.

Endpoint

Exposure

Exposure Parameters
Exposure 1:
Exposure duration: at least 2 years job experience before beginning of intervention, 90 days in a full time job during intervention

Exposure 1

Main characteristics
Frequency
Type
Exposure duration at least 2 years job experience before beginning of intervention, 90 days in a full time job during intervention
Exposure setup
Exposure source
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 6.49 µT minimum measured and calculated - -
magnetic flux density 39.25 µT maximum measured and calculated - -
electric field strength 4.89 V/m minimum measured and calculated - -
electric field strength 44.82 V/m maximum measured and calculated - -

Reference articles

  • Cam ST et al. (2011): Occupational exposure to magnetic fields from transformer stations and electric enclosures in Turkey.

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Time of investigation:
  • before exposure
  • after exposure

Main outcome of study (acc. to author)

A significant increase in the levels of superoxide dismutase and catalase enzyme activities and in the total antioxidative capacity was found in all vitamin-treated groups (groups 1-3) as well as a significant decrease in lipid peroxidation in the vitamin E (group 1) and C group (group 2) after the intervention compared to before. In all vitamin-treated groups, the number of red blood cells, hematocrit, the level of mean corpuscular hemoglobin and the mean corpuscular hemoglobin concentration were significantly increased after the intervention compared to before. In the control group, no significant changes between before and the interention were found. (Remark EMF-Portal: results for subjective symptoms are not mentioned.)
The authors conclude that administration of vitamin C and vitamin E might attenuate oxidative stress and improve hematological parameters in power plant workers.

Study character:

Study funded by

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