Study type: Medical/biological study (experimental study)

Single, brief exposure to a 50 Hz magnetic field does not affect the performance of an object recognition task in adult mice. med./bio.

Published in: Bioelectromagnetics 2001; 22 (1): 19-26

Aim of study (acc. to author)

To investigate the effects magnetic fields have on non-spatial working memory in mice.

Background/further details

In an object recognition task mice were first allowed to explore a stimulus object. Then mice were removed from the arena, exposed to a magnetic field and replaced in the test arena, which contained a novel object in addition to the original familiar object. The role (familiar vs. novel) and position of the two objects was counterbalanced and randomly assigned.Three different exposure groups (each n=17) and one sham exposure group (n=17) were studied.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 50 Hz
Exposure duration: continuous for 45 min

Exposure 1

Main characteristics
Frequency 50 Hz
Type
Waveform
Exposure duration continuous for 45 min
Exposure setup
Exposure source
Setup electromagnet consisting of two sets of aluminum coils, 25 cm apart; animals in 33 cm x 15 cm x 13 cm polycarbonate cages in the bore of the magnet
Sham exposure A sham exposure was conducted.
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 750 µT maximum measured - 7.5 µT, 75 µT, 750 µT

Reference articles

  • Kowalczuk CI et al. (1994): Effects of prenatal exposure to 50 Hz magnetic fields on development in mice: I. Implantation rate and fetal development.

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

During the first test phase, all groups showed similar levels of spontaneous exploratory activity.
During the second test phase, all groups showed comparable exploratory behavior: The familiar object was explored less than the novel object in all groups. No significant field-dependent effects on the performance of the task were observed at any magnetic flux density compared to sham exposed animals.
The results provide no evidence that non-spatial working memory was affected by acute exposure to a 50 Hz magnetic field in mice.

Study character:

Study funded by

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