Study type: Medical/biological study (experimental study)

Effect of pulsed magnetic fields on triglyceride and cholesterol levels in plasma of rats. med./bio.

Published in: Panminerva Med 1998; 40 (4): 276-279

Aim of study (acc. to author)

To investigate the effects of pulsed magnetic field (PMF) on cholesterol and triglyceride levels in blood plasma of rats.

Background/further details

Cholesterol and triglyceride levels in blood plasma are to a large extent due to liver function. To look for an effect of PMF exposure in liver function these parameters were selected. Also the ratio of liver to body weight were examined.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 12 Hz
Modulation type: pulsed
Exposure duration: 1 hr
Exposure 2: 50 Hz
Modulation type: pulsed
Exposure duration: 1 hr
Exposure 3: 100 Hz
Modulation type: pulsed
Exposure duration: 1 hr
Exposure 4: 300 Hz
Modulation type: pulsed
Exposure duration: 1 hr
Exposure 5: 460 Hz
Modulation type: pulsed
Exposure duration: 1 hr

Exposure 1

Main characteristics
Frequency 12 Hz
Type
Waveform
Exposure duration 1 hr
Modulation
Modulation type pulsed
Pulse width 7 µs
Rise time 70 ns
Fall time 700 ns
Additional info

Unipolar asymmetrical pulses with 90 µs pulse burst.

Exposure setup
Exposure source
  • two discs
Setup Rats were placed in 11 cm x 8 cm plastic boxes, 1 rat per box, each was put on an emitter disk.
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 6 mT - unspecified - -

Exposure 2

Main characteristics
Frequency 50 Hz
Type
Waveform
Exposure duration 1 hr
Modulation
Modulation type pulsed
Pulse width 7 µs
Rise time 70 ns
Fall time 700 ns
Additional info

Unipolar asymmetrical pulses with 90 µs pulse burst.

Exposure setup
Exposure source
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 6 mT - unspecified - -

Exposure 3

Main characteristics
Frequency 100 Hz
Type
Waveform
Exposure duration 1 hr
Modulation
Modulation type pulsed
Pulse width 7 µs
Rise time 70 ns
Fall time 700 ns
Additional info

Unipolar asymmetrical pulses with 90 µs pulse burst.

Exposure setup
Exposure source
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 6 mT - unspecified - -

Exposure 4

Main characteristics
Frequency 300 Hz
Type
Waveform
Exposure duration 1 hr
Modulation
Modulation type pulsed
Pulse width 7 µs
Rise time 70 ns
Fall time 700 ns
Additional info

Unipolar asymmetrical pulses with 90 µs pulse burst.

Exposure setup
Exposure source
  • two discs
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 6 mT - unspecified - -

Exposure 5

Main characteristics
Frequency 460 Hz
Type
Waveform
Exposure duration 1 hr
Modulation
Modulation type pulsed
Pulse width 7 µs
Rise time 70 ns
Fall time 700 ns
Additional info

Unipolar asymmetrical pulses with 90 µs pulse burst.

Exposure setup
Exposure source
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 6 mT - unspecified - -

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

Two different designs of experiment were carried out:
1) Following 1 h of exposure at different frequencies the parameters were examined 24 h after exposure. Cholesterol was significantly reduced at 12 Hz and 460 Hz. Triglycerides were reduced at 12 Hz and 100 Hz. At 12 Hz the liver to body ratio was increased. 50 Hz and 300 Hz exposures had no detectable effects.
2) Following 1 h of exposure at 12 Hz the parameters were examined at different time-points (directly after exposure, 3, 4, 6, 8, 16, 24, 48, and 96 h after exposure). The main fact was a decrease in cholesterol and triglyceride levels, most obvious after 16 h and 24 h, respectively. However, significant increases of cholesterol were noticed 3 h and 8 h after exposure. Also increased levels of triglycerides were found 48 h after exposure. Liver to body weight ratio was increased 24 h after exposure.

Study character:

Study funded by

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