Apoptosis is among other things induced by Fas. Fas/Apo 1 (CD95) belongs to the tumor necrosis factors (TNF). One way Fas acts is by elevating the ceramide synthesis. Also butyrate is known to suppress T cell viability through apoptotic mechanism.
Butyrate- and ceramide-induced apoptosis was not altered during microwave exposure. Microwave exposure did not alter the cell proliferation but slightly enhance the sensitivity to Fas-induced apoptosis. Microwave exposure leads only to a temperature increase of 0.1°C. However, temperature conditions of 37.5°C did not show any changes. The results suggest that the observed effects of microwave exposure on Fas-induced apoptosis in Jurkat cells are related to non-thermal mechanism.