Study type: Medical/biological study (experimental study)

Microwave exposure alters the expression of 2-5A-dependent RNase med./bio.

By: Krause D, Mullins JM, Penafiel LM, Meister R, Nardone RM
Published in: Radiat Res 1991; 127 (2): 164-170
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Aim of study (acc. to editor)

Three different cell lines were tested on effects of microwave exposure concerning cell proliferation rate, cell viability, and plating efficiency.

Background/further details

In addition the activity of two enzymes, 2'-5'-oligoadenylat synthetase and 2-5A-dependent endoribonuclease (RNase L), of murine L929 cells were studied in detail. The expression of these enzymes is among other things regulated by interferon.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 2.45 GHz
Modulation type: CW
Exposure duration: continuous, 4 h

Exposure 1

Main characteristics
Frequency 2.45 GHz
Type
Waveform
Charakteristic
Polarization
Exposure duration continuous, 4 h
Modulation
Modulation type CW
Exposure setup
Exposure source
Chamber TE10 mode,
Setup 4ml exposure tubes, 3,6ml suspension,perpendiucular to direction of propagation
Parameters
Measurand Value Type Method Mass Remarks
electric field strength 450 V/m - calculated - inside waveguide
power density 950 W/m² - calculated - -
magnetic field strength 630 A/m - calculated - inside waveguide
SAR 130 mW/g - calculated - -

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

For all three cell lines no alterations in cell viability, plating efficiency, or doubling time were noted for any of the exposure parameters measured compared to sham exposed controls.
For 2'-5'-oligoadenylate synthetase the microwave exposure did not alter the activity. The expression of 2-5A dependent endonuclease was increased by microwave exposure.

Study character:

Study funded by

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