To study whether a single millimeter wave treatment, that can produce opioid-related hypoalgesia, may also retard gut transit and colorectal passage in mice.
Endogenous and exogenous opioids are known to suppress gastrointestinal transit; the authors hypothesize that endogenous opioids are involved in millimeter wave treatment-induced hypoalgesia.
| Exposure | Parameters |
|---|---|
|
Exposure 1:
61.22 GHz
Exposure duration:
15 min
|
|
| Frequency | 61.22 GHz |
|---|---|
| Type | |
| Waveform | |
| Exposure duration | 15 min |
| Exposure source | |
|---|---|
| Setup | mice restrained in a plastic tube (8 cm long and 2.6 cm inner diameter). |
| Additional info | mouse nose was uncovered for exposure purpose |
| Measurand | Value | Type | Method | Mass | Remarks |
|---|---|---|---|---|---|
| power density | 15 µW/cm² | unspecified | measured | unspecified | - |
The data have shown that millimeter wave treatment does not significantly change small intestinal or colonic transit in mice. Thus, suppression of gastrointestinal motility should not be a setback in the clinical use of millimeter wave treatment.
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