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To study whether a single millimeter wave treatment, that can produce opioid-related hypoalgesia, may also retard gut transit and colorectal passage in mice.
Endogenous and exogenous opioids are known to suppress gastrointestinal transit; the authors hypothesize that endogenous opioids are involved in millimeter wave treatment-induced hypoalgesia.
ばく露時間: 15 min
|ばく露装置の詳細||mice restrained in a plastic tube (8 cm long and 2.6 cm inner diameter).|
|Additional information||mouse nose was uncovered for exposure purpose|
The data have shown that millimeter wave treatment does not significantly change small intestinal or colonic transit in mice. Thus, suppression of gastrointestinal motility should not be a setback in the clinical use of millimeter wave treatment.