Study type: Medical/biological study (experimental study)

Immunomodulatory effects of L-carnitine and q10 in mouse spleen exposed to low-frequency high-intensity magnetic field. med./bio.

Published in: Toxicology 2003; 187 (2-3): 171-181

Aim of study (acc. to author)

The effects of exposure of mice to a 50 Hz magnetic field and of a co-exposure with two immunostimulating substances on some immune parameters should be investigated.

Background/further details

Mice were divided into the following groups (n=6 each): 1) sodium chloride solution administration and exposure to the magnetic field, 2) coenzyme Q10 administration (200 mg/kg oral) and exposure and 3) L-carnitine administration (200 mg/kg intraperitoneal) and exposure. For each exposure group, a respective control group with the same administrations but without exposure was used. Administrations were conducted every second day 1 hour before the start of exposure.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 50 Hz
Exposure duration: continuous for 30 min/day, 3 days/week (every other day) for 2 weeks

Exposure 1

Main characteristics
Frequency 50 Hz
Type
Exposure duration continuous for 30 min/day, 3 days/week (every other day) for 2 weeks
Exposure setup
Exposure source
Setup three rectangular coils (each 22 cm x 12 cm with 760 turns of 1 mm copper wire) connected in parallel and wrapped around a wooden frame; up to 12 mice were placed inside the coil system, which was closed at both ends with plexiglass windows
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 20 mT - measured - vertical field

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • before exposure
  • after exposure

Main outcome of study (acc. to author)

Injections with salt solutions and exposure to the magnetic field (group 1) resulted in a significantly decreased spleen cell viability, proliferation of T lymphocytes and B lymphocytes, total count of white blood cells and body weight and a significantly increased amount of monocytes compared to the respective control group.
When injected with L-carnitine and exposed to the magnetic field (group 3), almost all these effects vanished and no significant differences were observed compared to the salt injected control group anymore. This protective effect was not detected in mice injected with coenzyme Q10 and exposure to the magnetic field (group 2).
The authors conclude that exposure of mice to a 50 Hz magnetic field might have adverse effects on the immune system and that co-exposure with L-carnitine, but not with coenzyme Q10, could mitigate these effects.

Study character:

Study funded by

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