Study type: Medical/biological study (experimental study)

Lack of alterations on meiotic chromosomes and morphological characteristics of male germ cells in mice exposed to a 60 Hz and 2.0 mT magnetic field. med./bio.

Published in: Bioelectromagnetics 2004; 25 (1): 63-68

Aim of study (acc. to author)

The study was undertaken to explore the effects of extremely low frequency magnetic field on mice germ cells in vivo.

Background/further details

The positive controls were mitomycin C treated animals.
Additionally, animals were co-exposed (magnetic field plus mitomycin C).
Nine mice were utilized for each treatment and control groups, giving a total of 72 examined animals.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 60 Hz
Exposure duration: continuous for 72 h
Exposure 2: 60 Hz
Exposure duration: repeated daily exposure, 8 h/day for 10 consecutive days

Exposure 1

Main characteristics
Frequency 60 Hz
Type
Waveform
Exposure duration continuous for 72 h
Exposure setup
Exposure source
Setup Animals placed in the middle of the solenoid where the MF was homogeneous
Additional info Another group was injected with 5 mg/kg Mitomycin-C and exposed to MF for 72 h.
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 2 mT effective value measured - -

Exposure 2

Main characteristics
Frequency 60 Hz
Type
Waveform
Exposure duration repeated daily exposure, 8 h/day for 10 consecutive days
Exposure setup
Exposure source
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 2 mT effective value measured - -

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

No statistically significant differences between exposed and sham exposed animals were observed. In contrast, the co-exposed (magnetic field plus mitomycin C) animals showed lower percentages of meiotic chromosome aberrations and sperm morphology abnormalities when compared with animals treated with mitomycin C alone.

Study character:

Study funded by

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