Study type: Medical/biological study (experimental study)

Evaluation of spermatogenesis and fertility in F1 male rats after in utero and neonatal exposure to extremely low frequency electromagnetic fields. med./bio.

Published in: Asian J Androl 2005; 7 (2): 189-194

Aim of study (acc. to author)

To study whether in utero and neonatal exposure to a 60 Hz extremely low frequency electromagnetic field results in spermatotoxicity and reproductive dysfunction in the F1 offspring of rats.

Background/further details

Pregnant rats were exposed continuously (21h/day) to a 60 Hz extremely low frequency electromagnetic field from day 6 of gestation through to day 21 of lactation.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 60 Hz
Exposure duration: continuous, 21 h/ day from day 6 of gestation to day 21 of lactation

Exposure 1

Main characteristics
Frequency 60 Hz
Type
Exposure duration continuous, 21 h/ day from day 6 of gestation to day 21 of lactation
Exposure setup
Exposure source
Chamber polycarbonate cages were placed on racks consisting of three levels (ten rats on each level). The spatial variation of the magnetic field was under 3% within the animal testing area (1 m x 1 m x 1 m).
Sham exposure A sham exposure was conducted.
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 500 mT unspecified measured - -
magnetic flux density 83.3 mT unspecified measured - -
magnetic flux density 5 mT unspecified measured - -

Reference articles

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • during exposure
  • after exposure

Main outcome of study (acc. to author)

No exposure-related alterations were revealed in exposed or sham-exposed rats with respect to the anogenital distance, preputial separation, testis weight, testicular histology, sperm count, daily sperm production, sperm motility, sperm morphology and reproductive capacity of F1 offspring.
The authors concluded that exposure of rats to a 60 Hz extremely low frequency electromagnetic field at field strengths of up to 500 mT from day 6 of gestation to day 21 of lactation did not produce any detectable alterations in offspring spermatogenesis and fertility.

Study character:

Study funded by

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