Study type: Medical/biological study (experimental study)

Whole-body exposure to 2.45 GHz electromagnetic fields does not alter anxiety responses in rats: a plus-maze study including test validation. med./bio.

Published in: Behav Brain Res 2005; 156 (1): 65-74

Aim of study (acc. to author)

To study anxiety responses in rats.

Background/further details

In a first phase of this investigation, a validation of the elevated plus-maze apparatus was performed in rats by testing anxiety response at various ambient light intensities (200, 30, 10 and 2.5 lux), as well as the effects of diazepam treatment (0.5 and 1.0 mg/kg, at 30 lux). Anxiety responses were revealed to decrease with decreasing light intensity and to be attenuated by diazepam treatment. Subsequently, a separate set of animals was exposed to 2.45 GHz electromagnetic fields for 45 min (at light intensity of 2.5 lux and 30 lux) to assess whether electromagnetic field exposure altered anxiety responses in the same apparatus.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 2.45 GHz
Modulation type: pulsed
Exposure duration: continuous for 45 min

Exposure 1

Main characteristics
Frequency 2.45 GHz
Charakteristic
  • guided field
Exposure duration continuous for 45 min
Modulation
Modulation type pulsed
Pulse width 2 µs
Repetition frequency 500 Hz
Exposure setup
Exposure source
  • circular waveguide (93 cm long, 20 cm in diameter)
Chamber Transparent cylindrical plastic chamber/20 cm long, 17.5 cm in diameter, 13.5 cm high.
Setup Each rats was placed in a cylindrical chamber located in the center of the waveguide.
Sham exposure A sham exposure was conducted.
Parameters
Measurand Value Type Method Mass Remarks
SAR 600 µW/g average over time calculated whole body determined by FDTD (finite difference time domain)
SAR 900 µW/g average over time calculated partial body brain averaged; determined by FDTD (finite difference time domain)

Reference articles

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

Whatever light intensity was used, electromagnetic field irradiation failed to induce any significant effect on anxiety responses in the plus maze. The present experiment shows that exposure to electromagnetic fields does not alter anxiety responses assessed in the elevated plus maze.

Study character:

Study funded by

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