Study type: Medical/biological study (experimental study)

Modification of tumor promotion in the mouse skin by exposure to an alternating magnetic field. med./bio.

Published in: Cancer Lett 1992; 65 (1): 1-7

Aim of study (acc. to author)

To investigate if an 60 Hz magnetic field could act as a tumor co-promoter in the SENCAR-mouse model.

Background/further details

DMBA and TPA (synonym PMA) were used to initiate the carcinogenic process and to promote tumor development, respectively. A total of 96 mice were used (2 groups of 48 animals each). Each mouse was treated with a single, subcarcinogenic DMBA dose (10 nmol). One week thereafter a weekly TPA treatment (0.3 µg) over the next 23 weeks was started. One group of animals served as sham-exposed control group. Each day randomly 3 animals of the other group were choosen to be exposed. Tumor development was physically examined each week.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 60 Hz
Exposure duration: repeated daily exposure, 6 h/day, 5 days a week

Exposure 1

Main characteristics
Frequency 60 Hz
Type
Waveform
Exposure duration repeated daily exposure, 6 h/day, 5 days a week
Exposure setup
Exposure source
Chamber acrylic exposure cage/ 0.1 m x 0.25 m x 0.18 m
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 2 mT unspecified unspecified - -

Reference articles

  • McLean JR et al. (1991): Cancer promotion in a mouse-skin model by a 60-Hz magnetic field: II. Tumor development and immune response.

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • during exposure
  • after exposure

Main outcome of study (acc. to author)

The percentage of mice with tumors and the mean number of tumor per mouse were statistically significant higher for the exposed group at week 18 of the experiment. However, at week 23 this differences were no longer significant.

Study character:

Study funded by

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