Study type: Medical/biological study (experimental study)

A 60-Hz magnetic field increases the incidence of squamous cell carcinomas in mice previously exposed to chemical carcinogens. med./bio.

Published in: Cancer Lett 1995; 92 (2): 121-125

Aim of study (acc. to author)

To investigate the effects of a 60 Hz magnetic field exposure on skin tumor development in the SENCAR-mouse-model.

Background/further details

DMBA and PMA were used to initiate and promote cancer development. A total of 96 mice were used in this study (2 groups/48 animals each). One group was magnetic field exposed, whereas the other was sham exposed. Each mouse obtained a single, sub-carcinogenic DMBA administration (10 nmol). One week thereafter the weekly administration of PMA (0.3 µg) began and were conducted over the next 23 weeks. Magnetic field exposure and sham exposure were conducted for additional 29 weeks (total exposure/sham exposure time 52 weeks).

Endpoint

Exposure

Exposure Parameters
Exposure 1: 60 Hz
Exposure duration: repeated daily exposure, 6 h/day, 5 days/week, 52 weeks

Exposure 1

Main characteristics
Frequency 60 Hz
Type
Waveform
Exposure duration repeated daily exposure, 6 h/day, 5 days/week, 52 weeks
Exposure setup
Exposure source
  • not specified
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 2 mT unspecified unspecified - -

Reference articles

  • McLean JR et al. (1991): Cancer promotion in a mouse-skin model by a 60-Hz magnetic field: II. Tumor development and immune response.

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • during exposure
  • after exposure

Main outcome of study (acc. to author)

The number of tumor-bearing mice was not significantly altered after 52 weeks. However, the number of squamous cell carcinomas in the magnetic field exposed group was statistically significant increased.

Study character:

Study funded by

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