Three independent experiments are discussed to evaluate the effects of 60 Hz magnetic fields on the growth and development of skin tumors (for the first of these replicate experiments see publication 1383) .
The well-known SENCAR mouse two-stage (initiation/promotion) skin tumor model was used. Tumorigenesis was initiated on the shaved backs of the animals by the application of DMBA (7,12-Dimethylbenzanthracene). One week following initiation, animals were treated with PMA (phorbol myristate acetate) for 23 weeks.
| Exposure | Parameters |
|---|---|
|
Exposure 1:
60 Hz
Exposure duration:
repeated daily exposure, 6 h/d, 5 d/week for 23 weeks
|
|
| Frequency | 60 Hz |
|---|---|
| Type | |
| Exposure duration | repeated daily exposure, 6 h/d, 5 d/week for 23 weeks |
| Exposure source |
|
|---|---|
| Chamber | acrylic cages/0.1 m x 0.25 m x 0.18 m |
| Measurand | Value | Type | Method | Mass | Remarks |
|---|---|---|---|---|---|
| magnetic flux density | 2 mT | mean | unspecified | - | - |
The data did not support a role for magnetic fields as a tumor co-promoter. This negative result could also be interpreted that the SENCAR mouse skin tumor model was not sensitive enough to detect the action of a weak co-promoter.
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