Study type: Medical/biological study (experimental study, review/survey)

The effect of 60 Hz magnetic fields on co-promotion of chemically induced skin tumors on SENCAR mice: a discussion of three studies. med./bio.

Published in: Environ Health Perspect 1997; 105 (1): 94-96

Aim of study (acc. to author)

Three independent experiments are discussed to evaluate the effects of 60 Hz magnetic fields on the growth and development of skin tumors (for the first of these replicate experiments see publication 1383) .

Background/further details

The well-known SENCAR mouse two-stage (initiation/promotion) skin tumor model was used. Tumorigenesis was initiated on the shaved backs of the animals by the application of DMBA (7,12-Dimethylbenzanthracene). One week following initiation, animals were treated with PMA (phorbol myristate acetate) for 23 weeks.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 60 Hz
Exposure duration: repeated daily exposure, 6 h/d, 5 d/week for 23 weeks

Exposure 1

Main characteristics
Frequency 60 Hz
Type
Exposure duration repeated daily exposure, 6 h/d, 5 d/week for 23 weeks
Exposure setup
Exposure source
  • double set of square
Chamber acrylic cages/0.1 m x 0.25 m x 0.18 m
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 2 mT mean unspecified - -

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • during exposure
  • after exposure

Main outcome of study (acc. to author)

The data did not support a role for magnetic fields as a tumor co-promoter. This negative result could also be interpreted that the SENCAR mouse skin tumor model was not sensitive enough to detect the action of a weak co-promoter.

Study character:

Study funded by

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