Study type: Medical/biological study (experimental study)

Effect of 26 week magnetic field exposures in a DMBA initiation-promotion mammary gland model in Sprague-Dawley rats. med./bio.

Published in: Carcinogenesis 1999; 20 (5): 899-904

Aim of study (acc. to author)

To investigate the effect of 26 week magnetic field exposures on chemically induced brest cancer in rats.

Background/further details

DMBA (7,12-dimethylbenzanthracene) was used as chemical agent to induce breast cancer. Three sets of experiments were conducted, each including 100 rats (see fields 1-3). A single 10 mg dose of DMBA was administered orally.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 50 Hz
Exposure duration: 18.5 h/day, 7 days/week, for 26 weeks
Exposure 2: 50 Hz
Exposure duration: 18.5 h/day, 7 days/week, for 26 weeks
Exposure 3: 60 Hz
Exposure duration: 18.5 h/day, 7 days/week, for 26 weeks

Exposure 1

Main characteristics
Frequency 50 Hz
Type
Waveform
Exposure duration 18.5 h/day, 7 days/week, for 26 weeks
Exposure setup
Exposure source
  • coil sets: 4 pairs of horizontal coils, 240mH,
Chamber 3 identical field generating coil sets in single room, 5 rats per polycarbonate cage 23x15x5in,
Setup once a week cages were rotated on racks
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 100 µT unspecified measured - -

Exposure 2

Main characteristics
Frequency 50 Hz
Type
Waveform
Exposure duration 18.5 h/day, 7 days/week, for 26 weeks
Exposure setup
Exposure source
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 500 µT unspecified measured - -

Exposure 3

Main characteristics
Frequency 60 Hz
Type
Waveform
Exposure duration 18.5 h/day, 7 days/week, for 26 weeks
Exposure setup
Exposure source
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 100 µT unspecified measured - -

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
  • breast
Time of investigation:
  • during exposure
  • after exposure

Main outcome of study (acc. to author)

No effect of magnetic field exposure on tumor size could be found. This study does not support the hypothesis that magnetic field exposure promotes breast cancer in this DMBA rat model

Study character:

Study funded by

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