Study type: Medical/biological study (experimental study)

Effect of 13 week magnetic field exposures on DMBA-initiated mammary gland carcinomas in female Sprague-Dawley rats. med./bio.

Published in: Carcinogenesis 1999; 20 (8): 1615-1620

Aim of study (acc. to author)

To investigate the effect of 13 week magnetic field exposures on chemically induced breast cancer in rats.

Background/further details

DMBA (7,12-dimethylbenzanthracene) was used as chemical agent to induce breast cancer. Two sets of experiments were conducted, each including 100 rats, and differ only in the total amount of DMBA applied (20 mg and 8 mg respectively).

Endpoint

Exposure

Exposure Parameters
Exposure 1: 50 Hz
Exposure duration: 18.5 h/day, 7 days/week for 13 weeks
Exposure 2: 60 Hz
Exposure duration: 18.5 h/day, 7 days/week for 13 weeks

Exposure 1

Main characteristics
Frequency 50 Hz
Type
Waveform
Exposure duration 18.5 h/day, 7 days/week for 13 weeks
Exposure setup
Exposure source
Setup coil sets consisting of four pairs of vertically oriented coils connected in series, stacked one above the other; to minimize stray fields the bottom and top pairs of coils produced magnetic fields in opposite directions
Sham exposure A sham exposure was conducted.
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 100 µT - - - -
magnetic flux density 500 µT - - - -

Exposure 2

Main characteristics
Frequency 60 Hz
Type
Waveform
Exposure duration 18.5 h/day, 7 days/week for 13 weeks
Exposure setup
Exposure source
Sham exposure A sham exposure was conducted.
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 100 µT - - - -

Reference articles

  • Boorman GA et al. (1999): Effect of 26 week magnetic field exposures in a DMBA initiation-promotion mammary gland model in Sprague-Dawley rats.

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
  • breast
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

No effect of magnetic field exposure on tumor size could be found. This study do not support the hypothesis that magnetic field exposure promotes breast cancer in this DMBA rat model.

Study character:

Study funded by

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