Amyloid beta is a peptide (39-43 amino acids) that is the main constituent of amyloid plaques in the brains of Alzheimer's disease patients. It is generated through cleavage of amyloid precursor protein (APP).
Exposure duration: continuous for 18 h
|Exposure duration||continuous for 18 h|
|magnetic flux density||3.1 mT||-||-||-||+/- 0.2 mT|
The exposure to low frequency electromagnetic fields for 18 hours caused a significant increase of amyloid beta secretion, including the isoform amyloid beta 1-42. The cell viability was not affected.
These data indicate that the exposure to low frequency electromagnetic fields stimulate the amyloid beta secretion in vitro, thus alluding to a potential link between low frequency electromagnetic fields exposure and amyloid precursor protein (APP) processing in the brain.