Study type: Medical/biological study (experimental study)

The mitochondria/caspase-dependent apoptotic pathway plays a role in the positive effects of a power frequency electromagnetic field on Alzheimer's disease neuronal model. med./bio.

Published in: J Chem Neuroanat 2020; 109: 101857

Aim of study (acc. to author)

The aim of the study was to investigate the effects induced by 50 Hz magnetic field exposure on an Alzheimer's disease neuronal model and to provide an initial understanding of the molecular mechanisms, which might provide the basis for Alzheimer's disease treatment.

Background/further details

Rat pheochromocytoma cells were induced into an Alzheimer's disease neuronal model using nerve growth factor and 25-35.
The cells were randomly divided into four groups: 1) control; 2) cells exposed to magnetic field; 3) cells treated with ; 4) cells treated with and exposed to magnetic field.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 50 Hz
Exposure duration: 24 h

Exposure 1

Main characteristics
Frequency 50 Hz
Type
Exposure duration 24 h
Exposure setup
Exposure source
Setup the exposure and sham exposure system were located inside an incubator and consisted of a voltage-regulator, two enameled wire coils of 20 x 10 x 25 cm, and a drawer-shelf
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 100 µT - - - -

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

Apoptosis was inhibited following magnetic field exposure. In addition, magnetic field exposure significantly reduced the expression of Caspase 8, Caspase 3, and CytC, but increased the Bcl-2/Bax ratio of the cells.The magnetic field exposure seemed to have no effect on the expression of Fas and TNFR1.
The results showed that the mitochondria/caspase-dependent apoptotic pathway plays an important role in the positive effects of magnetic field (50 Hz) exposure on an Alzheimer's disease neuronal model. The study indicated that the 50 Hz magnetic field exposure might have potential therapeutic value for Alzheimer's disease. The underlying molecular mechanisms still need further studies.

Study character:

Study funded by

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