To study whether or not an extremely low-frequency magnetic field exposure and aluminium treatment have synergistic effects on Alzheimer's disease pathogenesis by investigating the effects of extremely low-frequency magnetic field exposure with or without chronic aluminium treatment in rats.
Rats were divided into the following groups (each group n=10): 1.) sham exposure, 2.) oral aluminium administration, 3.) magnetic field exposure with oral aluminium administration, or 4.) magnetic field exposure without oral aluminium administration. The experiments were repeated three times.
Exposure duration: continuous for 12 weeks
|Exposure duration||continuous for 12 weeks|
|magnetic flux density||100 µT||-||-||-||-|
After 12 weeks, aluminium groups (groups 2 and 3) showed learning and memory impairments as well as morphological changes in the brain, including neuronal cell loss and a high density of beta-amyloid protein in the hippocampus and cerebral cortex. Extremely low-frequency magnetic exposure alone (group 4) showed no significant effect on Alzheimer's disease pathogenesis. Co-exposure of extremely low-frequency magnetic field and aluminium (group 3) did not induce more damage than aluminium treatment alone (group 2).
The data showed no evidence of any association between extremely low-frequency magnetic exposure exposure (100 µT, 50 Hz) and Alzheimer's disease, and extremely low-frequency magnetic field exposure did not influence the pathogenesis of Alzheimer's disease induced by aluminium overload.