Study type: Medical/biological study (experimental study)

Extremely low-frequency magnetic exposure appears to have no effect on pathogenesis of Alzheimer's disease in aluminum-overloaded rat. med./bio.

Published in: PLoS One 2013; 8 (8): e71087-1-e71087-8

Aim of study (acc. to author)

To study whether or not an extremely low-frequency magnetic field exposure and aluminium treatment have synergistic effects on Alzheimer's disease pathogenesis by investigating the effects of extremely low-frequency magnetic field exposure with or without chronic aluminium treatment in rats.

Background/further details

Rats were divided into the following groups (each group n=10): 1.) sham exposure, 2.) oral aluminium administration, 3.) magnetic field exposure with oral aluminium administration, or 4.) magnetic field exposure without oral aluminium administration. The experiments were repeated three times.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 50 Hz
Exposure duration: continuous for 12 weeks

General information

Rats of the control groups were placed in a geomagnetic environment (ambient magnetic field (50 Hz) <400 nT; geomagnetic field 9-32 µT)

Exposure 1

Main characteristics
Frequency 50 Hz
Type
Exposure duration continuous for 12 weeks
Exposure setup
Exposure source
Chamber rats were housed in plastic cages
Setup pair of Helmholtz coils (diameter: 1400 mm); rats placed in the center of the coils; magnetic field direction was vertical; room temperature 23±1°C
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 100 µT - - - -

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated material:
Investigated organ system:
Time of investigation:
  • during exposure
  • after exposure

Main outcome of study (acc. to author)

After 12 weeks, aluminium groups (groups 2 and 3) showed learning and memory impairments as well as morphological changes in the brain, including neuronal cell loss and a high density of beta-amyloid protein in the hippocampus and cerebral cortex. Extremely low-frequency magnetic exposure alone (group 4) showed no significant effect on Alzheimer's disease pathogenesis. Co-exposure of extremely low-frequency magnetic field and aluminium (group 3) did not induce more damage than aluminium treatment alone (group 2).
The data showed no evidence of any association between extremely low-frequency magnetic exposure exposure (100 µT, 50 Hz) and Alzheimer's disease, and extremely low-frequency magnetic field exposure did not influence the pathogenesis of Alzheimer's disease induced by aluminium overload.

Study character:

Study funded by

Related articles