Study type: Medical/biological study (experimental study)

Low-frequency magnetic fields do not aggravate disease in mouse models of Alzheimer's disease and amyotrophic lateral sclerosis. med./bio.

Published in: Sci Rep 2015; 5: 8585

Aim of study (acc. to author)

The effects of a chronic exposure of mice to a 50 Hz magnetic field on the development of Alzheimer's disease and amyotrophic lateral sclerosis should be investigated.

Background/further details

APP23 mice with an overexpression of the amyloid precursor protein (APP) were used as a model for early onset of Alzheimer's disease. SOD1G85R and SODG93A mice with an overexpression of mutant superoxide dismutase 1 (SOD-1) were used as models for amyotrophic lateral sclerosis. SOD1WT mice, overexpressing human wild type SOD-1, were used as negative controls for the SOD mutation. All mice were 2 month old when the experiment started.
The following groups were used: 1) APP23 mice exposed to the magnetic field (n=?), 2) sham exposed APP23 mice (n=?), 3) SOD1G85R mice exposed to the magnetic field (n=135), 4) sham exposed SOD1G85R mice (n=138), 5) SOD1G93A mice exposed to the magnetic field (n=122), 6) sham exposed SOD1G93A mice (n=110), 7) non-exposed SOD1WT mice (n=?), 8) non-exposed non-transgenic littermates (n=?).

Endpoint

Exposure

Exposure Parameters
Exposure 1: 50 Hz
Exposure duration: continuous for 16 months

Exposure 1

Main characteristics
Frequency 50 Hz
Type
Exposure duration continuous for 16 months
Exposure setup
Exposure source
Chamber cages without metal
Setup several mouse cages were placed in one module on three levels within the homogeneous field; Merritt coils consisted of two coils of 26 and 11 turns each which were connected in series; the cable consisted of five wires with a total cross-section area of 16 mm2; wires were wrapped in aluminum foil to block electric fields; exposure units were shielded to prevent fringing
Sham exposure A sham exposure was conducted.
Additional info modules for sham exposure looked identical to the modules for exposure, but wires were turned after half of the turns
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 1 mT - measured - -

Reference articles

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • before exposure
  • during exposure
  • after exposure

Main outcome of study (acc. to author)

No significant differences were found in any parameter between exposed and sham exposed animals of all strains, respectively.
The authors conclude that chronic exposure of mice to a 50 Hz magnetic field has no effects on the development, course or symptoms of Alzheimer's disease and amyotrophic lateral sclerosis.

Study character:

Study funded by

Related articles