Study type: Medical/biological study (experimental study)

Effects of subchronic exposure to a 1439 MHz electromagnetic field on the microcirculatory parameters in rat brain. med./bio.

Published in: In Vivo 2007; 21 (4): 563-570

Aim of study (acc. to author)

To study the effects of repeated radiofrequency electromagnetic field exposure (4 weeks, subchronic) on cerebral microcirculation, including blood-brain barrier function, in rat brain.

Background/further details

30 rats were divided into three groups: exposure group, sham exposure group, and cage control group (each group consisted of 10 rats) and rats were non-anesthetized during exposure. A "closed cranial window" was implanted into the parietal region.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 1,439 MHz
Modulation type: pulsed
Exposure duration: repeated daily exposure, 60 min/day, 5 days/week, for 4 weeks
  • SAR: 2.4 W/kg average over mass (brain)
  • SAR: 0.64 W/kg average over mass (whole body)

Exposure 1

Main characteristics
Frequency 1,439 MHz
Type
Charakteristic
Exposure duration repeated daily exposure, 60 min/day, 5 days/week, for 4 weeks
Additional info Watanabe S, Taki M, Yamanaka Y: A microwave exposure setup for the head of Sprague-Dawley rats. Proc. XXVIth General Assembly of the International Union of Radio Science (URSI), pp 863, 1999.
Modulation
Modulation type pulsed
Pulse width 6.67 ms
Repetition frequency 50 Hz
Additional info

TDMA signal for PDC (Japanese mobile phone standard) having a peak power 3-fold higher than the temporal average

Exposure setup
Exposure source
Setup Rats in acrylic holders were placed on a carousel with their heads towards the central antenna [Watanabe et al., 1999].
Sham exposure A sham exposure was conducted.
Parameters
Measurand Value Type Method Mass Remarks
SAR 2.4 W/kg average over mass - brain -
SAR 0.64 W/kg average over mass - whole body -

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • before exposure
  • during exposure
  • after exposure

Main outcome of study (acc. to author)

The three microcirculatory parameters examined (blood brain barrier permeability, leukocyte behavior, plasma velocity) revealed no significant changes after four weeks' exposure. The data suggest that there were no effects on the cerebral microcirculation under the given radiofrequency electromagnetic field exposure conditions.

Study character:

Study funded by

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