Study type: Medical/biological study (experimental study)

Potential Impact of Simulated Mobile Phone Radiation on Blood-Brain Barrier. med./bio.

Published in: Electromagn Biol Med 2005; 24 (3): 355-358

Aim of study (acc. to author)

1) To study brain manganese (Mn) levels in rats with or without experimental manganese administration (2.88 mg Mn2+, applied at the start of the experiment) and with or without the exposure to electromagnetic field at the end of acute or longterm exposures.
2) To observe rats behaviour at the end of longterm exposures (after 12 weeks) with possible implication to manganese or electromagnetic field exposure.

Background/further details

Manganese has a neurotoxic potential as a result of professional (metalurgy) and nonprofessional (traffic) exposure, when in excess in the brain.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 900 MHz
Exposure duration: continuous for 30 min
Exposure 2: 900 MHz
Exposure duration: repeated daily exposure, 30 min/day for 6 or 12 weeks

General information

Four groups of rats per test (acute or subchronic) were treated as follows: no exposure, exposure to inorganic manganese (Mn), exposure to EMF, and exposure to EMF + Mn. Inorganic manganese compound (MnSO4*4H2O) was applied at the start of the experiment by intratracheal instillation.

Exposure 1

Main characteristics
Frequency 900 MHz
Type
Exposure duration continuous for 30 min
Additional info acute exposure
Modulation
Modulation type unspecified
Exposure setup
Exposure source
Distance between exposed object and exposure source 5 cm
Setup Rats were placed in Plexiglas tubes with only the head part sticking out. The antenna was located at a distance of 5 cm from the head of the rat.
Parameters
Measurand Value Type Method Mass Remarks
power 1 W unspecified unspecified - -

Exposure 2

Main characteristics
Frequency 900 MHz
Type
Exposure duration repeated daily exposure, 30 min/day for 6 or 12 weeks
Additional info subchronic exposure
Modulation
Modulation type unspecified
Exposure setup
Exposure source
Parameters
Measurand Value Type Method Mass Remarks
power 1 W unspecified unspecified - -

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

In acute test, significant increase in brain manganese level was found in rats exposed to both factors (electromagnetic fields and manganese) as compared to Mn administration only.
Within subchronic test such interaction did not appear, but in vivo observation of exposed rats (exposure to Mn and/or electromagnetic field) at the end of the test have demonstrated signficant behavioral changes as compared to unexposed animals.

Study character:

Study funded by

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