To study whether dopaminergic receptors were involved in extremely low frequency magnetic field induced behavioral changes, because in a previous study (publication 10671), the authors found that exposure to an extremely low frequency magnetic field increased levels of dopamine and its metabolites in the rat striatum.
30 minutes before exposure mice were treated with SCH23390 hydrochloride (SCH, D1-like antagonist) at 0.03 or 0.1 mg/kg or (RS)-(±) sulpiride (Sulp, D2-like antagonist) at 10 or 20 mg/kg.
It is known that dopaminergic D1-like receptor stimulation leads to a robust induction of striatal c-Fos expression.
| Exposure | Parameters |
|---|---|
|
Exposure 1:
60 Hz
Exposure duration:
1 h/day for 1 or 7 days
|
|
| Frequency | 60 Hz |
|---|---|
| Type | |
| Exposure duration | 1 h/day for 1 or 7 days |
| Exposure source | |
|---|---|
| Setup | three Helmholtz coils in a wooden frame parallel to each other |
| Sham exposure | A sham exposure was conducted. |
| Measurand | Value | Type | Method | Mass | Remarks |
|---|---|---|---|---|---|
| magnetic flux density | 0.3 mT | - | - | - | - |
| magnetic flux density | 2.4 mT | - | - | - | - |
Exposure to extremely low frequency magnetic field for one or seven days enhanced locomotor activity in a time-dependent manner. This hyperlocomotor activity paralleled an increase in c-Fos-like immunoreactivity. Pretreatment with a dopaminergic D1-like receptor antagonist (SCH23390), but not with a dopaminergic D2-like receptor antagonist (sulpiride), inhibited magnetic field-induced increased locomotor activity and c-Fos-immunoreactivity.
Thus, the data indicate that extremely low frequency magnetic field-induced behavioral responses are, at least in part, mediated by activation of dopamine D1-like receptors.
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